Toxicants: Harmful impact on reproductive biology
DOI:
https://doi.org/10.53573/rhimrj.2023.v10n01.009Keywords:
Toxicants, reproductive biology, zebrafish, biodiversityAbstract
Reproductive success is a vital factor for existence of organisms, also It ensures the establishment of genetic line through generations. The reproductive success is influenced by several environmental and biological factors. There are several studies and hypothesis have proved that the same toxic substance can produce different effects among species and between sexes due to variations in absorption, distribution, metabolism, and other biological processes. Chronic exposure of different pesticide and fungicide (acephate, fluorides) results in sex-specific reproductive toxicity in different model organisms like Danio rerio (zebrafish), Drosophila melanogaster and albino rat, and studies have found that females are more affected than males. Similarly, in Wistar rats, exposure to inorganic mercury leads to distinct lipotoxic effects and accumulation of mercury in different organs of males and females. These findings highlight reproductive biology as a critical biological parameter in toxicological studies. Therefore, toxicity induced sex bias is one of the key factors into environmental risk assessment, drug safety evaluation, and biodiversity conservation strategies.
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